Programme scientifique

WEDNESDAY, APRIL 5

Welcome cocktail reception

            Opening and welcoming speech (B. Korkmaz, France)

            Memorial talk: Prof. Niels Borregaard’s biography (O. Sørensen, Denmark)

Opening lecture

            Neutrophil serine proteases and their inhibitors: balancing defense and destruction(D. Jenne, Germany)

THURSDAY, APRIL 6

SESSION I: Structure and activity of cathepsin C

Cysteine cathepsins: oldies but goldies proteases always on the agenda (G. Lalmanach, France)

Cathepsin C gene (CTSC): structure and genetic alterations (P. Fergelot, France)

Cathepsin C and Papillon-Lefèvre syndrome (C. Moss, UK)

Selected talk

Selected talk

SESSION II: Cathepsin C targets and their pathophysiology

Neutrophil serine proteases in vasculitis (R. Kettritz,  Germany)

Characterization of neutrophil disfunction in Papillon-Lefèvre syndrome patients (I. Chapple, UK)

Mast cell proteases in asthma (G.H. Caughey, USA)

Selected talk

Selected talk

SESSION III: Pharmacological targeting of cathepsin C

Cathepsin C substrates and inhibitors (A. Lesner, Poland)

Cathepsin C inhibition in mice model of rheumatoid arthritis (J. Pedersen, Denmark)

Cathepsin C inhibition in macaque model of lung inflammation (B. Korkmaz, France)

Selected Talk

Selected Talk

Concluding remarks (F. Gauthier / P. Diot, France)